They can also cause unwanted side effects like flushing, headaches, or changes in vision. ![]() Prescription medications don’t help all cases of ED. Previous sexual trauma like rape and abuse also can lead to ED. Once an episode of ED occurs, the fear of it happening again can block a man’s ability to achieve a subsequent erection. Stress, anxiety, depression, low self-esteem, and relationship issues can all have negative effects on reaching and maintaining an erection. Physical and medical conditions aren’t the only sources of ED.
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